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Staring At Breasts Increases Heart Health
>> dr. nick delgado: hello, i’m dr. nickdelgado, and i’m with dr. jennifer landa, and she’s written a book about libido forwomen, and men, too, right? that’s true! but you did a wonderful talk on estrogen dominance.where did these problems of estrogen dominance come from? where are the endocrine disrupters? the doctorsare intrigued but i don’t think the general
Staring At Breasts Increases Heart Health, public is aware of this problem as much asthey should be. tell me about it. >> dr. jennifer landa: so, basically, estrogendominance is an imbalance between estrogen and progesterone, meaning there’s too muchestrogen influence, and too little progesterone influence, and there’s multiple places thatit comes from. but one really important place
that we need to concern ourselves with isendocrine disrupters, or edcs (endocrine disrupter chemicals). so, what are those? those are things in our environment that canmess up our hormones, quite simply. one of the big examples of this, is something calledbp-a, bisphenol-a, shows up in multiple different places. one of the places we used to see ita lot was in plastics, but the awareness kind of got driven about plastics. people startedto figure it out. it was in baby bottles, it was everywhere, and this chemical thatwas in the baby bottles acts like a hormone in your body. it can bind to your estrogen receptors, itcan sit on your estrogen receptors longer
than estrogen itself, turning on the estrogenreceptor and never turning it off. that can increase the risk of all kinds of things,including even cancers, like: breast cancer, uterine cancer, ovarian cancer. it can causeall kinds of havoc, but it can also cause everyday problems like pms, you know, bloating,breast tenderness, irritability, moodiness, all of that stuff; it can also cause thyroidendometriosis, and a big infertility driver. that’s one thing that we’ve seen: womenthat have higher exposure to bp-a, and we can measure exposure to bp-a in women’surine. we see that the women who have a higher levelof bp-a, have less likelihood of being able to get pregnan twhen they do infertility treatments.
>> dr. nick delgado: well, now they have urinetests where you can do 4-points (morning, mid-day, afternoon, and evening), so you canactually get measurements for adrenal function, cortisol, you can get the estrogen metabolites,the androgens. this is a great breakthrough to be able to help doctors to measure peoplewho are at risk for these very chemicals. now., does the body distinguish between thetoxic chemicals and the actual influence of say, diet, and other factors that cause estrogenmetabolism problems? does it actually pick up these differences? >> dr. jennifer landa: so, i think the testyou’re talking about is physician’s lab 5-point urine test, and the 5-point urinetest that looks at a whole hormonal profile.
it looks at the three main estrogens. it looksat progesterone, testosterone, dhea, cortisol, as you mentioned, and it also looks at theestrogen metabolites, which are the break-down products of estrogen. and what’s really interesting with thisendocrine disruptors, like you were mentioning, is that the endocrine disruptors actuallyinfluence the way we metabolize estrogen, and it influences in a negative direction. like i said, that’s one of the reasons thatthese endocrine disruptors can increase the risk of cancer, and so this test, picks upthings like that indirectly, but it’s not looking, really at bp-a, measuring bp-a levelsin urine, or anything like that.
>> dr. nick delgado: what i noticed from yourlecture in your slides, is you mentioned the solutions to these abnormal estrogen metabolites.you specifically identified 16-a-hydroxyestrone, and you made the reference that 2-hydroxyestroneis beneficial, but then you have to methylate it and bring it through it’s pathways toa safer form. what was interesting, and i’m glad you broughtthis up that the early pioneers looking at estrogen metabolism probably had a financialinterest because they were working with dim, or some of the product introductions, butnow, as recently as 2014, we’re seeing studies that finally confirm these findings, the 2:16ratio, and the necessity to metabolize these estrogens. very important, right?
>> dr. nick delgado: absolutely. i tell mypatients in a very simple way that you’re looking at the, way we’re looking at thebreakdown of estrogen in your body, to see whether it’s safe or not. i like that highwayanalogy. >> dr. jennifer landa: so, estrogen has toget out of your body somehow, right? so i tell people to picture estrogen that has todrive out of your body by one of three different highways. there’s the 2 highway, the 4 highway,and the 16 highway. the 2 highway is by far your safest highway.your 4 highway is your most dangerous highway. your 16 highway, you know, so-so and the jury’sstill out on that, but the bottom line is you want to drive most of your traffic downthe 2 highway, and once it’s down the 2-highway,
you want to make sure that it’s gettingoff the right exit, and the right exit is the 2-methoxy exit. so when i’m helpingwomen, or men, when i’m helping them with their estrogen metabolism, i’ve got twogoals: one is to drive toward 2-hydroxy versus the4 or the 16, the second goal is to make sure that they’remethylating well, that is, once they have 2-hydroxy that they should be methylatingit to 2-methoxy. that also works with the 4, so if you have people who are making toomuch 4 hydroxy, which is the most dangerous since that’s the one that is gonna increasethe risk of cancer. so if they’ve got 4, their only chance of neutralizing it, is methylatingit to 4-methoxy. so that’s my two goals:
raising 2-hydroxy, and methylating 2 and 4-hydroxyover to 2 and 4-methoxy. >> dr. nick delgado: so, from a lifestylemedicine standpoint, people should eat more cruciferous vegetables, particularly raw cruciferousvegetables, they should eat a whole, healthy, whole plant-based diet, minimize use of excessoils and chemical exposure, and basically start taking supplementations that are richin dim (dylmethane) indol-3-carbinol. then to methylate, they need the tmg (trimethylglycine),dmg (dimethylglycine). people also need probably some sam-e some of these nice 5-methyltetrafolate,the folic acid, so we use these things to help people in addition to a healthy diet,to usher the metabolism to the right highway, then to the right exit. exactly!
and as they exit out, the body is purifiedand safer, and the man-boobs disappear. the problems in the women--the thyroids, and thetumor incidences-- all these things tend to decrease and disappear if they are in themidst of a problem related to estrogen metabolism. it very well may help in the healing processor the recovery process. is that all true? >> dr. jennifer landa: that is all true. yeah.that’s why, of course, why i want to drive down a safer highway, and get off the saferexit to alleviate symptoms, and to help prevent disease. >> dr. nick delgado: so if a doctor just doesa saliva test or a blood test, they may miss these critical highways that are only reallyusually measured best by urine metabolites:
urine tests . >> dr. jennifer landa: yeah, the only wayto measure these critical highways and things are by urinary metabolites, so if you’reonly measuring saliva, or only measuring blood, you’re not going to be able to get a readon what these things are doing. >> dr. nick delgado: so, it’s appropriate,though, to do all three. maybe they’re doing saliva to measure cortisol changes and adrenalfunction, they’re doing blood to look at the binding proteins, and they’re lookingat estrogen metabolites and the androgen metabolites, and also the cortisol metabolites, right?you’ve got to look at it all. >> dr. jennifer landa: so what you’re askingme is basically the question that all doctors
who are beginning this ask me, they say, “well,which test is best? which one do you want me to do? right?†and the answer is, there’s no good answerto that question, because yeah, you want to measure certain things. you’re gonna wantto measure saliva, certain things in blood, certain things in urine, and then certainthings in poop too, right? the stool. >> dr. nick delgado: and actually, you mentionedthat the super-poopers, the women who have 4 bowel movements a day, actually had thelowest rate of breast cancer overall. so we’re actually seeing the changes, and a lot ofthese abnormal metabolites are excreted out of the bowel movements, aren’t they?
>> dr. jennifer landa: yeah, absolutely. soi tell people, before they detoxify, they’ve got to make sure that they’re pooping well.they’ve got to make sure they’re eliminating. because you don’t want to drive all thesehormones through the metabolism, and then not be able to excrete them. that’s goingto back up the whole system. so, yeah you want to make sure people are eliminating wellwhen you detoxify them. >> dr. nick delgado: dr. jennifer landa, agreat message. stay tuned for our next segment.
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